The main focus of the Li lab is to elucidate the molecular and epigenetic basis of cancer with the ultimate goal of developing protein- and peptide-based diagnostic or therapeutic agents for cancer.
We use an integral approach that combines molecular, cellular, structural, and proteomic information to obtain a comprehensive picture of how proteins interact to transduce cellular signals and how aberrant changes in cellular signal transduction lead to cancer. We are particularly interested in understanding the role of post-translational modifications, including Tyr/Ser/Thr phosphorylation and Lys/Arg methylation on histone and non-histone proteins, in regulating such cellular processes as proliferation, differentiation, migration, apoptosis and DNA damage response. Because protein phosphorylation and methylation are intimately involved in tumorigenesis and metastasis, we hope our research to generate novel diagnostic and therapeutic agents that target these modifications.
Dual Oxidase Maturation factor 1 (DUOXA1) overexpression increases reactive oxygen species production and inhibits murine muscle satellite cell differentiation
[News updates, December 2013]
[News updates, October 2013]
[Links to News articles, May 2013]
Click "Read more..." below to watch YouTube video.