The main focus of the Li laboratory is to elucidate the molecular basis of protein-protein interaction and understand how aberrant changes in protein function and connectivity alter cellular behaviour and lead to diseases.
We use an integrated approach that combines molecular, cellular, and proteomic information to obtain a comprehensive picture of how certain proteins interact and transduce signals in a cell. We are particularly interested in understanding the mechanisms of asymmetric cell division, cell polarity and adhesion, and how adaptor proteins function in facilitating immunoreceptor signaling. Moreover, we employ peptide and protein arrays to identify protein-protein interaction networks underlying these important biological events.
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